Meet the Antibiotic Hunters—a team of professional and student scientists at the Tiny Earth Network who search for new antibiotics in the soil.

Resources available for learning about this lab include:
• Interactive cards designed to introduce students to scientists in a more personal way
• A video with a personal story that explains why the lab's research matters in real life
• Questions to consider that will spark connection, reflection, and conversation
• An interactive video experience where you can ask questions of scientists in the lab and learn about their research
• An inquiry-based activity that focuses on doing science, using some of the same science practices that the lab uses
• An educator guide with information about standards alignment, curriculum connections, and tips for using the media resources

These resources are part of Meet the Lab, a collection of educational resources for middle school science classrooms.

Summary
Table of Contents
Teachers can use this lesson to have students investigate how bacteria are important in cleaning up the environment, as well as all of the roles that bacteria play in maintaining a healthy body or ecosystem.

Students are introduced to the concept of engineering biological organisms and studying their growth to be able to identify periods of fast and slow growth. They learn that bacteria are found everywhere, including on the surfaces of our hands. Student groups study three different conditions under which bacteria are found and compare the growth of the individual bacteria from each source. In addition to monitoring the quantity of bacteria from differ conditions, they record the growth of bacteria over time, which is an excellent tool to study binary fission and the reproduction of unicellular organisms.

In this inquiry activity, students generate investigable questions to explore the link between hygiene/cleanliness and bacteria growth/population. The students will present their conclusions, and video clips containing additional information will be discussed.

Students will investigate how much bacteria surrounds them in their daily lives, even though they cannot see it with the naked eye.  Students will conduct an experiment to obtain samples from a classroom surface of their choice, both before the surface is cleaned and afterwards.  Students will incubate the petri dishes under a heat lamp for a week, and then compare the pre-washed sample with the post-washed sample.  Students will try to identify the type of bacteria by using internet or paper bacterial guides, and to find out if their bacteria is helpful, harmful, or benign.  Also, students will be reminded of the importance of frequent hand washing, as well as how infections are spread when proper hygiene is not used.

Students construct paper recombinant plasmids to simulate the methods genetic engineers use to create modified bacteria. They learn what role enzymes, DNA and genes play in the modification of organisms. For the particular model they work on, they isolate a mammal insulin gene and combine it with a bacteria's gene sequence (plasmid DNA) for production of the protein insulin.

Teachers can use this lesson to have students investigate how bacteria are important in cleaning up the environment, as well as all of the roles that bacteria play in maintaining a healthy body or ecosystem.

How can you tell if harmful bacteria are in your food or water that might make you sick? What you eat or drink can be contaminated with bacteria, viruses, parasites and toxins—pathogens that can be harmful or even fatal. Students learn which contaminants have the greatest health risks and how they enter the food supply. While food supply contaminants can be identified from cultures grown in labs, bioengineers are creating technologies to make the detection of contaminated food quicker, easier and more effective.

Students learn about a special branch of engineering called bioremediation, which is the use of living organisms to aid in the clean-up of pollutant spills. Students learn all about bioremediation and see examples of its importance. In the associated activity, students conduct an experiment and see bioremediation in action!

Students design and conduct experiments to determine what environmental factors favor decomposition by soil microbes. They use chunks of carrots for the materials to be decomposed, and their experiments are carried out in plastic bags filled with dirt. Every few days students remove the carrots from the dirt and weigh them. Depending on the experimental conditions, after a few weeks most of the carrots will have decomposed completely.

" In this class, students engage in independent research projects to probe various aspects of the physiology of the bacteriumĺĘPseudomonas aeruginosa PA14, an opportunistic pathogen isolated from the lungs of cystic fibrosis patients. Students use molecular genetics to examine survival in stationary phase, antibiotic resistance, phase variation, toxin production, and secondary metabolite production. Projects aim to discover the molecular basis for these processes using both classical and cutting-edge techniques. These include plasmid manipulation, genetic complementation, mutagenesis, PCR, DNA sequencing, enzyme assays, and gene expression studies. Instruction and practice in written and oral communication are also emphasized. WARNING NOTICE The experiments described in these materials are potentially hazardous and require a high level of safety training, special facilities and equipment, and supervision by appropriate individuals. You bear the sole responsibility, liability, and risk for the implementation of such safety procedures and measures. MIT shall have no responsibility, liability, or risk for the content or implementation of any of the material presented. Legal Notice "

This lesson describes the major components and functions of the immune system and the role of engineers in keeping the body healthy (e.g., vaccinations and antibiotics, among other things). This lesson also discusses how an astronaut's immune system is suppressed during spaceflight due to stress and other environmental factors.

Build a gene network! The lac operon is a set of genes which are responsible for the metabolism of lactose in some bacterial cells. Explore the effects of mutations within the lac operon by adding or removing genes from the DNA.

Build a gene network! The lac operon is a set of genes which are responsible for the metabolism of lactose in some bacterial cells. Explore the effects of mutations within the lac operon by adding or removing genes from the DNA.

Students learn about water poverty and how water engineers can develop appropriate solutions to a problem that is plaguing nearly a sixth of the world's population. Students follow the engineering design process to design a gravity-fed water system. They choose between different system parameters such as pipe sizes, elevation differentials between entry and exit pipes, pipe lengths and tube locations to find a design that provides the maximum flow and minimum water turbidity (cloudiness) at the point of use. In this activity, students play the role of water engineers by designing and building model gravity-fed water systems, learning the key elements necessary for viable projects that help improve the lives people in developing communities.

Students are introduced to a challenge question. Towards answering the question, they generate ideas for what they need to know about medicines and how they move through our bodies, watch a few short videos to gain multiple perspectives, and then learn lecture material to obtain a basic understanding of how antibiotics kill bacteria in the human body. They learn why different forms of medicine (pill, liquid or shot) get into the blood stream at different speeds.

Students conduct experiments to determine what environmental factors favor decomposition by soil microbes. They use chunks of carrots for the materials to be decomposed, and their experiments are carried out in plastic bags filled with dirt. Every few days students remove the carrots from the dirt and weigh them. Depending on the experimental conditions, after a few weeks most of the carrots have decomposed completely.

This article by the National Library of Medicine teaches readers how germs make people ill. It includes several sections - what microbes are, the types of microbes (including viruses, bacteria, fungi, helminths, protozoa, and prions), how we encounter microbes, the mechanisms by which germs may enter a human host, how pathogens cause illness, and some examples of germs that cause illness. Students can make flashcards of each microbe and its mechanism of causing illness as they read. This article is great for comprehension and retention as it includes pictures, microscopic images, and diagrams. By reading this article, students should have a clear understanding of how each type of microbes contributes to illness.

This unit covers the processes of photosynthesis, extinction, biomimicry and bioremediation. In the first lesson on photosynthesis, students learn how engineers use the natural process of photosynthesis as an exemplary model of a complex yet efficient process for converting solar energy to chemical energy or distributing water throughout a system. In the next lesson on species extinction, students learn that it is happening at an alarming rate. Students discover that the destruction of habitat is the main reason many species are threatened and how engineers are trying to stop this habitat destruction. The third lesson introduces students to the idea of biomimicry or looking to nature for engineering ideas. And, in the fourth and final lesson, students learn about a specialty branch of engineering called bioremediation the use of living organisms to aid in the clean up of pollutant spills.

Introducing a range of microbiological techniques including aseptic technique, how to inoculate flasks for experiments, use of API strips to identify bacteria. Other instructional resources include a video on using a portable autoclave for laboratory classes and Gram staining.