This course explores the physical, ecological, technological, political, economic, and cultural implications of big plans and mega-urban landscapes in a global context. It uses local and international case studies to understand the process of making major changes to urban landscape and city fabric, and to regional landscape systems. It includes lectures by leading practitioners. The assignments consider planning and design strategies across multiple scales and time frames.

" This course is offered for graduate students who are interested in the interdisciplinary study of bio-inspired structures. The intent is to introduce students to newly inspired modern advanced structures and their applications. It aims to link traditional advanced composites to bio-inspired structures and to discuss their generic properties. A link between materials design, strength and structural behavior at different levels (material, element, structural and system levels) is made. For each level, various concepts will be introduced. The importance of structural, dynamic, thermodynamic and kinetic theories related to such processing is highlighted. The pedagogy is based on active learning and a balance of guest lectures and hands-on activities."

This peer-reviewed publication contains over 70 MAC and PC tools, simulations, databases, and other resources developed for undergraduate biology.

This course focuses on the interaction of chemical engineering, biochemistry, and microbiology. Mathematical representations of microbial systems are featured among lecture topics. Kinetics of growth, death, and metabolism are also covered. Continuous fermentation, agitation, mass transfer, and scale-up in fermentation systems, and enzyme technology round out the subject material.

This is an introductory course in biochemistry, designed for both biology and chemical engineering majors.

A consistent theme in this course is the development of a quantitative understanding of the interactions of biological molecules from a structural, thermodynamic, and molecular dynamic point of view. A molecular simulation environment provides the opportunity for you to explore the effect of molecular interactions on the biochemical properties of systems. Topics covered include: Protein Function, Structure and Function of Carbohydrates, Lipids and Biological Membranes, Metabolism, Nucleic and Acid and Biochemistry.

" The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing. This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format. Acknowledgments Development of this course was funded through an HHMI Professors grant to Professor Catherine L. Drennan."

Considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. Focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control.

Each term, the class selects a new set of professional journal articles on bioengineering topics of current research interest. Some papers are chosen because of particular content, others are selected because they illustrate important points of methodology. Each week, one student leads the discussion, evaluating the strengths, weaknesses, and importance of each paper. Subject may be repeated for credit a maximum of four terms. Letter grade given in the last term applies to all accumulated units of 16.459.

" This course does not seek to provide answers to ethical questions. Instead, the course hopes to teach students two things. First, how do you recognize ethical or moral problems in science and medicine? When something does not feel right (whether cloning, or failing to clone) ‰ŰÓ what exactly is the nature of the discomfort? What kind of tensions and conflicts exist within biomedicine? Second, how can you think productively about ethical and moral problems? What processes create them? Why do people disagree about them? How can an understanding of philosophy or history help resolve them? By the end of the course students will hopefully have sophisticated and nuanced ideas about problems in bioethics, even if they do not have comfortable answers."

" This course is designed for advanced undergraduate and graduate students with an interest in using primary research literature to discuss and learn about current research around sulfur biogeochemistry and astrobiology."

This interdisciplinary course provides a hands-on approach to students in the topics of bioinformatics and proteomics. Lectures and labs cover sequence analysis, microarray expression analysis, Bayesian methods, control theory, scale-free networks, and biotechnology applications. Designed for those with a computational and/or engineering background, it will include current real-world examples, actual implementations, and engineering design issues. Where applicable, engineering issues from signal processing, network theory, machine learning, robotics and other domains will be expounded upon.

This page, presented by MIT and made available online via the university's Open Courseware site, presents a series of materials on biological engineering. Topics include introduction to biological engineering design, systems microbiology, computation for biological engineers and molecular principles of biomaterials. Materials are at both the undergraduate and graduate school levels. OpenCourseWare is free educational material online. Video lectures, assignments and exams are included. No registration or enrollment is required to use the materials.

This course illustrates how knowledge and principles of biology, biochemistry, and engineering are integrated to create new products for societal benefit. It uses a case study format to examine recently developed products of pharmaceutical and biotechnology industries: how a product evolves from initial idea, through patents, testing, evaluation, production, and marketing. Emphasizes scientific and engineering principles; the responsibility scientists, engineers, and business executives have for the consequences of their technology; and instruction and practice in written and oral communication. The topic focus of this class will vary from year to year. This version looks at inflammation underlying many diseases, specifically its role in cancer, diabetes, and cardiovascular disease.

This course covers sensing and measurement for quantitative molecular/cell/tissue analysis, in terms of genetic, biochemical, and biophysical properties. Methods include light and fluorescence microscopies; electro-mechanical probes such as atomic force microscopy, laser and magnetic traps, and MEMS devices; and the application of statistics, probability and noise analysis to experimental data.

In this course problems from biological engineering are used to develop structured computer programming skills and explore the theory and practice of complex systems design and construction.

This graduate course will introduce students to the processes controlling phytoplankton, zooplankton, heterotrophic bacterial and benthic infaunal growth and abundance. We'll do a broad-scale survey of patterns of productivity and abundance in the coastal zones, upwelling centers, gyres, and the deep sea. We'll briefly survey ecosystem simulation models, especially those applicable to the Gulf of Maine. Readings will be from the primary literature and a few book chapters. The effects of anthropogenic effects on marine communities will be stressed throughout. Calculus will be used throughout the course, but there is no formal calculus requirement.

"This course covers the principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs."

Analyzes computational needs of clinical medicine reviews systems and approaches that have been used to support those needs, and the relationship between clinical data and gene and protein measurements. Topics: the nature of clinical data; architecture and design of healthcare information systems; privacy and security issues; medical expertsystems; introduction to bioinformatics. Case studies and guest lectures describe contemporary systems and research projects. Term project using large clinical and genomic data sets integrates classroom topics.

This course provides intensive coverage of the theory and practice of electromechanical instrument design with application to biomedical devices. Students will work with MGH doctors to develop new medical products from concept to prototype development and testing. Lectures will present techniques for designing electronic circuits as part of complete sensor systems. Topics covered include: basic electronics circuits, principles of accuracy, op amp circuits, analog signal conditioning, power supplies, microprocessors, wireless communications, sensors, and sensor interface circuits. Labs will cover practical printed circuit board (PCB) design including component selection, PCB layout, assembly, and planning and budgeting for large projects. Problem sets and labs in the first six weeks are in support of the project. Major team-based design, build, and test project in the last six weeks. Student teams will be composed of both electrical engineering and mechanical engineering students.

Seminars exploring current research and topical issues in the biomedical sciences, addressed at the general theme of innovation. Seminars are organized in blocks with related content, and are presented by prominent outside speakers as well as by HST faculty members and graduate students. Each seminar block includes several semi-weekly presentations, in addition to wide-ranging discussions among speakers, faculty, and students. Discussions involve issues such as relations between presented research areas, requirements for further advances in the "state of the art", the role of enabling technologies, the responsible practice of biomedical research, and career paths in the biomedical sciences. This course consists of a series of seminars focused on the development of professional skills. Each semester focuses on a different topic, resulting in a repeating cycle that covers medical ethics, responsible conduct of research, written and oral technical communication, and translational issues. Material and activities include guest lectures, case studies, interactive small group discussions, and role-playing simulations.