Explores the changing roles, ethical conflicts, and public perceptions of science and scientists in American society from World War II to the present. Studies specific historical episodes focusing on debates between scientists and the contextual factors influencing their opinions and decisions. Topics include the atomic bomb project, environmental controversies, the Challenger disaster, biomedical research, genetic engineering, (mis)use of human subjects, scientific misconduct and whistleblowing.

Students construct paper recombinant plasmids to simulate the methods genetic engineers use to create modified bacteria. They learn what role enzymes, DNA and genes play in the modification of organisms. For the particular model they work on, they isolate a mammal insulin gene and combine it with a bacteria's gene sequence (plasmid DNA) for production of the protein insulin.

" This course does not seek to provide answers to ethical questions. Instead, the course hopes to teach students two things. First, how do you recognize ethical or moral problems in science and medicine? When something does not feel right (whether cloning, or failing to clone) ‰ŰÓ what exactly is the nature of the discomfort? What kind of tensions and conflicts exist within biomedicine? Second, how can you think productively about ethical and moral problems? What processes create them? Why do people disagree about them? How can an understanding of philosophy or history help resolve them? By the end of the course students will hopefully have sophisticated and nuanced ideas about problems in bioethics, even if they do not have comfortable answers."

Students are introduced to the concept and steps of the engineering design process and taught how to apply it. Students first receive some background information about biomedical engineering (aka bioengineering). Then they learn about material selection and material properties by using a provided guide. In small groups, students learn of their design challenge (improve a cast for a broken arm), brainstorm solutions, are given materials and create prototypes. To finish, teams communicate their design solutions through class poster presentations.

In this video segment adapted from NOVA scienceNOW, scientists discuss a family of genes called FOXO that can significantly extend life span in worms—and in humans.

Life as an emergent property of networks of chemical reactions involving proteins and nucleic acids. Mathematical theories of metabolism, gene regulation, signal transduction, chemotaxis, excitability, motility, mitosis, development, and immunity. Applications to directed molecular evolution, DNA computing, and metabolic and genetic engineering.

In this activity students will research the ethical and practical arguments in favor of cloning and against cloning. They will understand the argumentative and persuasive use of language through developing an ad campaign to try to persuade the audience to either support or refute cloning. Students will research, identify key points, and develop their own ad.

This video from Nature offers a description of desirable traits in beef and dairy cattle.

In this video segment from Nature, learn about six different breeds of cattle.

In this animation produced by WGBH and Digizyme, Inc., see how molecules of DNA are separated using gel electrophoresis, and how this process enables scientists to compare the molecular variations of two or more DNA samples.

" This is an advanced course on modeling, design, integration and best practices for use of machine elements such as bearings, springs, gears, cams and mechanisms. Modeling and analysis of these elements is based upon extensive application of physics, mathematics and core mechanical engineering principles (solid mechanics, fluid mechanics, manufacturing, estimation, computer simulation, etc.). These principles are reinforced via (1) hands-on laboratory experiences wherein students conduct experiments and disassemble machines and (2) a substantial design project wherein students model, design, fabricate and characterize a mechanical system that is relevant to a real world application. Students master the materials via problems sets that are directly related to, and coordinated with, the deliverables of their project. Student assessment is based upon mastery of the course materials and the student's ability to synthesize, model and fabricate a mechanical device subject to engineering constraints (e.g. cost and time/schedule)."

In this video excerpt from NOVA, learn about the advantages, disadvantages, and ethical implications of preimplantation genetic diagnosis, or PGD, a technique used to screen embryos created through in vitro fertilization for diseases.

Fundamentals of Biology focuses on the basic principles of biochemistry, molecular biology, genetics, and recombinant DNA. These principles are necessary to understanding the basic mechanisms of life and anchor the biological knowledge that is required to understand many of the challenges in everyday life, from human health and disease to loss of biodiversity and environmental quality.

Students read a scientific article about a research study done in India about genetically modified cotton.  Upon finishing the article student answer a number of literacy based questions about the article to both assess their vocabulary and understanding of the content of the article.  This is a great quick assignment to allow students to practice literacy as well as introducing them to a higher level reading material.  

In this lab, gel electrophoresis will be used to separate the dyes present in different flavors of Kool-Aid. In a normal research setting, samples of various DNA, RNA, or proteins would be run on this type of system. However, in this lab, we will be substituting various flavors of Kool-Aid for the DNA samples.This experiment will introduce you to the basics of gel electrophoresis, introduction to color theory, and how the eye perceives color.Also a virtual lab has been included to allow students to perform electrophoresis online.  This can be a great introductory activity before doing the Kool-aid Lab or can be a substitution if you do not have electrophoresis equipment.You will need gel electrophoresis equipment to conduct the Kool Aid lab.

Express yourself through your genes! See if you can generate and collect three types of protein, then move on to explore the factors that affect protein synthesis in a cell.

In this animation produced by WGBH and Digizyme, Inc., see how bacterial plasmids are engineered to clone or express genes that code for proteins such as human insulin.

Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts. From the course home page: In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology.

" This class is a project-based introduction to the engineering of synthetic biological systems. Throughout the term, students develop projects that are responsive to real-world problems of their choosing, and whose solutions depend on biological technologies. Lectures, discussions, and studio exercises will introduce (1) components and control of prokaryotic and eukaryotic behavior, (2) DNA synthesis, standards, and abstraction in biological engineering, and (3) issues of human practice, including biological safety; security; ownership, sharing, and innovation; and ethics. Enrollment preference is given to freshmen. This subject was originally developed and first taught in Spring 2008 by Drew Endy and Natalie Kuldell. Many of Drew's materials are used in this Spring 2009 version, and are included with his permission. This OCW Web site is based on the OpenWetWare class Wiki, found at OpenWetWare: 20.020 (S09)"

Students learn how engineers apply their understanding of DNA to manipulate specific genes to produce desired traits, and how engineers have used this practice to address current problems facing humanity. They learn what genetic engineering means and examples of its applications, as well as moral and ethical problems related to its implementation. Students fill out a flow chart to list the methods to modify genes to create GMOs and example applications of bacteria, plant and animal GMOs.