Deals with the specific functions of neurons, the interactions of neurons in development, and the organization of neuronal ensembles to produce behavior, by functional analysis of mutations and molecular analysis of their genes. Concentrates on work with nematodes, fruit flies, mice, and humans.

This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?

This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts. From the course home page: In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology.

This course will provide a gentle, yet intense, introduction to programming using Python for highly motivated students with little or no prior experience in programming. The course will focus on planning and organizing programs, as well as the grammar of the Python programming language. The course is designed to help prepare students for 6.01 Introduction to EECS. 6.01 assumes some knowledge of Python upon entering; the course material for 6.189 has been specially designed to make sure that concepts important to 6.01 are covered. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month.

This course introduces the parallel evolution of life and the environment. Life processes are influenced by chemical and physical processes in the atmosphere, hydrosphere, cryosphere and the solid earth. In turn, life can influence chemical and physical processes on our planet. This course explores the concept of life as a geological agent and examines the interaction between biology and the earth system during the roughly 4 billion years since life first appeared.

This course deals with mechanics of deformation of the crust and mantle, with emphasis on the importance of different rheological descriptions: brittle, elastic, linear and nonlinear fluids, and viscoelastic.

In this year's Geodynamics Seminar, we will explore the depth and breadth of scientific research related to Earth's present and past ice-sheets, glaciers and sea-ice, as well as extraterrestrial planetary ice. Invited speakers have been chosen from experts in the current frontiers in ice-related research, including planetary ice, climate records from polar and tropical ice cores, the Snowball Earth, subglacial volcanoes, ice rheology, ice sheet modeling, ice microkinetics, glacial erosion and tectonics, subglacial life and polar remote sensing. A field trip to Iceland in Summer 2006 will allow us to view some of the island's ice caps and glacial geology, the exposed mid Atlantic Ridge and evidence of ice-volcano interactions.

Introduction to discrete and computational geometry. Topics covered: planar graphs, geometric graphs, the theory of crossings, extremal graph theory, arrangements of curves and points in the plane (mainly pseudolines and pseudocircles), problems involving distances, Gallai-Sylvester-type problems, Davenport-Schinzel sequences. Emphasis on teaching methods in combinatorial geometry. Many results presented are recent, and include open problems.

This course is an intensive introduction to architectural design tools and process, and is taught through a series of short exercises. The conceptual basis of each exercise is in the interrogation of the geometric principles that lie at the core of each skill. Skills covered in this course range from techniques of hand drafting, to generation of 3D computer models, physical model-building, sketching, and diagramming. Weekly lectures and pin-ups address the conventions associated with modes of architectural representation and their capacity to convey ideas. This course is tailored and offered only to first-year M.Arch students.

A rigorous introduction designed for mathematicians into perturbative quantum field theory, using the language of functional integrals. Basics of classical field theory. Free quantum theories. Feynman diagrams. Renormalization theory. Local operators. Operator product expansion. Renormalization group equation. The goal is to discuss, using mathematical language, a number of basic notions and results of QFT that are necessary to understand talks and papers in QFT and string theory.

This is a second-semester graduate course on the geometry of manifolds. The main emphasis is on the geometry of symplectic manifolds, but the material also includes long digressions into complex geometry and the geometry of 4-manifolds, with special emphasis on topological considerations.

The topic for Fall 2006 is short film and radio plays. This course investigates current trends and topics in German literary, theater, film, television, radio, and other media arts productions. Students analyze media texts in the context of their production, reception, and distribution as well as the public debates initiated by these works. The topic for Fall 2006 is German Short Film, a popular format that represents most recent trends in film production, and German Radio Art, a striving genre that includes experimental radio plays, sound art, and audio installations. Special attention will be given to the representation of German minorities, contrasted by their own artistic expressions reflecting changes in identity and a new political voice. Students have the opportunity to discuss course topics with a writer, filmmaker, and/or media artist from Germany. The course is taught in German.

" This course gives an introduction to German language and culture. The focus is on acquisition of vocabulary and grammatical concepts through active communication. Audio, video, and printed materials provide direct exposure to authentic German language and culture. A self-paced language lab program is fully coordinated with the textbook/workbook. The first semester covers the development of effective basic communication skills."

This course expands skills in speaking, reading, listening, and writing. Students develop analytic and interpretative skills through the reading of a full-length drama as well as short prose and poetry (Biermann, Brecht, DĚ_rrenmatt, Tawada and others) and through media selections on contemporary issues in German-speaking cultures. Coursework includes discussions and compositions based on these texts, and review of grammar and development of vocabulary-building strategies. It is recommended for students with two years of high school German.

Expansion of basic communication skills and further development of linguistic competency. Review and completion of basic grammar, building of vocabulary, and practice in writing short essays. Reading of short literary texts. Exposure to history and culture of German-speaking countries through audio, video, and Web materials. In this course students are exposed to history and culture of German-speaking countries through audio, video, and Web materials. It focuses on the expansion of basic communication skills and further development of linguistic competency, and includes the review and completion of basic grammar, building of vocabulary, and practice in writing short essays. Students will also read short literary texts.

Development of interpretive skills, using literary texts (B. Brecht, S. Zweig) and contemporary media texts (film, TV broadcasts, Web materials). Discussion and exploration of cultural topics in their current social, political, and historical context via hypermedia documentaries. Further refinement of oral and written expression and expansion of communicative competence in practical everyday situations.

Prepares students for working and living in German-speaking countries. Focus on current political, social, and cultural issues, using newspapers, journals, TV, radio broadcasts, and Web sources from Germany, Austria, and Switzerland. Emphasis on speaking, writing, and reading skills for professional contexts. Activities include: oral presentations, group discussions, guest lectures, and interviews with German speakers. No listeners.

Examines the historical, political, and sociological forces that shape present-day Germany. Topics include: value changes in postwar society, coping with the legacy of the past, multiculturalism in Germany, change of gender roles, cultural differences between East and West after the unification, the role of environmentalism, the process of European integration, and Germany and its neighbors. Draws on current articles, texts, and videos from newspapers, journals, the web, and German TV. Taught in English. This course focuses on main currents in contemporary German literary and visual culture. Taking Nietzsche's thought as a point of departure, students will survey the dialectics of tradition and modernity in both Germany and other European countries, particularly the UK, France, Denmark, and Poland. Primary works are drawn from literature, cinema, art, and performance, including works by Peter Sloterdijk, Thomas Vinterberg, and Michel Houellebecq.

An old saying holds that ‰ŰĎthere are many more good ideas in the world than good ideas implemented.‰Ű This is a case-based introduction to the fundamentals of effective implementation. Developed with the needs and interests of planners--but also with broad potential application--in mind, this course is a fast-paced, case-driven introduction to developing strategy for organizations and projects, managing operations, recruiting and developing talent, taking calculated risks, measuring results (performance), and leading adaptive change, for example where new mental models and habits are required but also challenging to promote. Our cases are set in the U.S. and the developing world and in multiple work sectors (urban redevelopment, transportation, workforce development, housing, etc.). We will draw on public, private, and nonprofit implementation concepts and experience.