Consideration of some substantial twentieth-century poetic voices. Authors vary, but may include Moore, Frost, Eliot, Stevens, and Pound. This course considers some of the substantial early twentieth-century poetic voices in America. Authors vary, but may include Moore, Frost, Eliot, Stevens, and Pound. We'll read the major poems by the most important poets in English in the 20th century, emphazinig especially the period between post-WWI disillusionment and early WW II internationalism (ca. 1918-1940). Our special focus this term will be how the concept of "the Image" evolved during this period. The War had undercut beliefs in master-narratives of nationalism and empire, and the language-systems that supported them (religious transcendence, rationalism and formalism). Retrieving energies from the Symbolist movements of the preceding century, early 20th century poets began to rethink how images carry information, and in what ways the visual, visionary, and verbal image can take the place of transcendent beliefs. New theories of linguistics and anthropology helped to advance this interest in the artistic/religious image. So did Freud. So did Charlie Chaplin films. We'll read poems that pay attention both to this disillusionment and to the compensatory joyous attention to the image: to ideas of the poet-as-language-priest, aesthetic-experience-as-displaced-religious impulse, to poetry as faith, ritual, and form.

This course will consider the degree and nature of the modular organization of the mind and brain. We will focus in detail on the domains of objects, number, places, and people, drawing on evidence from behavioral studies in human infants, children, normal adults, neurological patients, and animals, as well as from studies using neural measures such as functional brain imaging and ERPs. With these domains as examples, we will address broader questions about the role of domain-general and domain-specific processing systems in mature human performance, the innateness vs. plasticity of encapsulated cognitive systems, the nature of the evidence for such systems, and the processes by which people link information flexibly across domains.

This class covers molecular-level engineering and analysis of chemical processes. Use of chemical bonding, reactivity, and other key concepts in the design and tailoring of organic systems are discussed. Specific class topics include application and development of structure-property relationships, and descriptions of the chemical forces and structural factors that govern supramolecular and interfacial phenomena for molecular and polymeric systems.

This course covers all aspects of molecular biosignatures, such as their pathways of lipid biosynthesis, the distribution patterns of lipid biosynthetic pathways with regard to phylogeny and physiology, isotopic contents, occurrence in modern organisms and environments, diagenetic pathways, analytical techniques and the occurrence of molecular fossils through the geological record. Students analyze in depth the recent literature on chemical fossils. Lectures provide background on the subject matter. Basic knowledge of organic chemistry required. Students taking graduate version complete additional assignments.

" This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics."

An introductory course in the molecular biology of the auditory system. First half focuses on human genetics and molecular biology, covering fundamentals of pedigree analysis, linkage analysis, molecular cloning, and gene analysis as well as ethical/legal issues, all in the context of an auditory disorder. Second half emphasizes molecular approaches to function and dysfunction of the cochlea, and is based on readings and discussion of research literature.

This course develops and applies scaling laws and the methods of continuum and statistical mechanics to biomechanical phenomena over a range of length scales, from molecular to cellular to tissue or organ level.

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework. This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to give guest lectures.

This courses focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations. This term, we focus on hepatocellular carcinoma (HCC), chronic-active hepatitis, and hepatitis virus infections. In addition to lectures, students work in teams to critically evaluate and present primary scientific papers.

" This course will focus on issues that arise in contemporary public debate concerning matters of social justice. Topics will likely include: euthanasia, gay marriage, racism and racial profiling, free speech, hunger and global inequality. Students will be exposed to multiple points of view on the topics and will be given guidance in analyzing the moral frameworks informing opposing positions. The goal will be to provide the basis for respectful and informed discussion of matters of common moral concern."

Presents a rational basis for the preliminary design of motion-sensitive structures. Topics include: analytical and numerical techniques for establishing the optimal stiffness distribution, the role of damping in controlling motion, tuned mass dampers, base isolation systems, and an introduction to active structural control. Examples illustrating the application of the motion-based design paradigm to building structures subjected to wind and seismic excitation are discussed.

Multi-scale systems differ from traditional macro-scale systems in that the multi-scale systems use components from two or more scales (i.e. nano, micro, meso, and macro-scales). Subject provides the skills required to design and manufacture multi-scale systems. Emphasis is placed on understanding the fundamental differences between traditional macro-scale system design and the design of multi-scale systems. Topics include design methodologies, modeling approaches, analytic tools, and manufacturing processes. Examples drawn from a diverse range of applications, including automobiles, fiber optic equipment, electronic test equipment, and micro/meso-scale machinery. Students master the materials through problem sets and a substantial term project.

Languages and compilers to exploit multithreaded parallelism. Implicit parallel programming using functional languages and their extensions. Higher-order functions, non-strictness, and polymorphism. Explicit parallel programming and nondeterminism. The lambda calculus and its variants. Term rewriting and operational semantics. Compiling multithreaded code for symmetric multiprocessors and clusters. Static analysis and compiler optimizations.

This course covers differential, integral and vector calculus for functions of more than one variable. These mathematical tools and methods are used extensively in the physical sciences, engineering, economics and computer graphics.

This course is a continuation of 18.014. It covers the same material as 18.02 (Multivariable Calculus), but at a deeper level, emphasizing careful reasoning and understanding of proofs. There is considerable emphasis on linear algebra and vector integral calculus.

Computer-aided design methodologies for synthesis of multivariable feedback control systems. Performance and robustness trade-offs. Model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; nonlinear effects. Computer-aided (MATLAB) design homework using models of physical processes. This course uses computer-aided design methodologies for synthesis of multivariable feedback control systems. Topics covered include: performance and robustness trade-offs; model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; and nonlinear effects. The assignments for the course comprise of computer-aided (MATLABĺ¨) design problems.

Growth and development of normal bone and joints, the process of mineralization, the biophysics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements.

Directed composition of larger forms of original writing involving voices and/or instruments. Includes a weekly seminar in composition for the presentation and discussion of student work in progress. Students are expected to produce at least one substantive work, performed in public, by the end of the term. Contemporary compositions and major works from twentieth-century music literature are studied. Meets with graduate subject 21M.505, but assignments vary.

"This course is a survey of perceptual and cognitive aspects of the psychology of music, with special emphasis on underlying neuronal and neurocomputational representations and mechanisms. Basic perceptual dimensions of hearing (pitch, timbre, consonance/roughness, loudness, auditory grouping) form salient qualities, contrasts, patterns and streams that are used in music to convey melody, harmony, rhythm and separate voices. Perceptual, cognitive, and neurophysiological aspects of the temporal dimension of music (rhythm, timing, duration, temporal expectation) are explored. Special topics include comparative, evolutionary, and developmental psychology of music perception, biological vs. cultural influences, Gestaltist vs. associationist vs. schema-based theories, comparison of music and speech perception, parallels between music cognition and language, music and cortical action, and the neural basis of music performance."